Autologous
Exosomes
AutologIX
AutologIX is a protocol for obtaining a concentrate of autologous exosomes from platelet-rich plasma derived from the patient’s blood. This is enabled by a ready-to-use system consisting of the ProtSmart6 ultraconcentrator and Idria G tubes. It is currently the only researched system for the extraction and ultraconcentration of exosomes available on the Polish market. Two medical devices play a key role in this process:
PROTSMART6
A Class IIa medical device – a selective exosome concentrator using ultrafiltration technology with special filters containing hundreds of pores. The filter’s permeability is approximately ⏈15,000 KDa, and the perfusion diameter is < 5 nm. Due to its ability to selectively concentrate and ultrafilter, water and salt ion fragments are expelled into the waste bag, while exosomes, proteins, and cells are collected inside the filter with a special membrane whose high filtration capacity results from its structure (the inner wall features a high density of small pores).
IDRIA G
H(2 Class IIB medical-grade tubes) – a medical device designed to prepare autologous platelet-rich plasma concentrate from the patient’s blood. During centrifugation with IDRIA G, vesicles are released and remain suspended in the plasma.
The set also includes: butterfly needle with holder, 2 x 20 ml syringes.
To properly perform the procedure, a horizontal centrifuge with adequate centrifugal force and optimal spinning parameters is necessary – allowing the collection of undamaged microvesicles that release exosomes at high concentration, while maintaining their full regenerative potential. We also offer such a centrifuge.
What are exosomes and how do they work?
Autologous exosomes are used in various fields of medicine, including orthopaedics, dermatology, pain management, wound healing, hair loss therapy, and rejuvenation treatments. What gives them their regenerative and reparative properties? It's worth knowing!
Exosomes are…
Extracellular vesicles (EVs) surrounded by a phospholipid bilayer, released into the extracellular space. They carry nucleic acids, proteins, and lipids from the cells they originate from. Exosomes deliver this cargo to recipient cells, acting as mediators of intercellular communication in both physiological and pathological conditions. They also serve as vehicles for transporting genetic material between cells.
They have the ability to...
Transmit critical intercellular information. During inflammation, they stimulate the immune response and exhibit antibacterial activity. It is also known that once absorbed by stem cells, exosomes release their contents into the cells, significantly influencing the metabolic dynamics of stem cells and enhancing their regenerative potential.
AutologIX is a protocol for obtaining a concentrate of autologous exosomes from the patient’s platelet-rich plasma (PRP), which is then administered into the skin via mesotherapy.
Indications:
- Skin rejuvenation with improvement in tone, texture, elasticity, and uniformity of the dermal layer
- Reduction of wrinkles and filling of fine lines
- Revitalisation of the eye contour
- Rejuvenation of the skin on the hands, face, and neck
- Accelerated healing of the skin following more invasive procedures, e.g. surgery
- Treatment of hair loss – including alopecia areata and androgenetic alopecia, as well as support during hair transplantation
- Reduction of inflammation
Exos on the metabolism of local cells (including MSCs and ASCs). The procedure is repeated no sooner than approximately 9 to 16 months later! In hair loss therapy, only two sessions are performed, spaced 2–3 weeks apart.
