New in 2026!
MEC Regenerate®

After years of fascination with immediate results and visible volumization, aesthetic medicine is entering a phase of redefining the concept of youth and an era of controlled regeneration. Certified, biocompatible products that activate the skin’s natural renewal processes – delivering long-lasting results – are now taking center stage.

We present Mec Regenerate® – the first MDR-certified biostimulator, developed and manufactured by 303 Pharma Srl, an Italian pharmaceutical company specializing in advanced biotechnologies and recombinant collagen, recognized as a pioneer in medical and aesthetic regenerative solutions. Its purpose is to regenerate the extracellular matrix (ECM), in Italian — Matrice ExtraCellulare – hence the name.

Next-generation stimulator

Mec Regenerate® is a next-generation biostimulator that moves beyond tissue stimulation through irritation and foreign body response, acting instead via biomimetic signaling. MEC Regenerate® supports gradual, biologically synchronized tissue renewal, respecting the natural rhythm of extracellular matrix regeneration. It represents a new level of balance between efficacy and safety.

Unlike traditional fillers or fast-acting stimulators, MEC Regenerate® does not aim to deliver an immediate volumizing effect. Instead, it initiates a controlled, multi-stage process of dermal reconstruction, optimizing the tissue’s ability to rebuild collagen and elastin networks over time. As a result, its action is both safe and predictable. Each component activates at the appropriate biological phase following injection, triggering a cascade of tissue repair processes. The product has been designed for long-term regeneration of the extracellular matrix (ECM), restoring elasticity, firmness, and tissue density while preserving the natural harmony of facial features as they evolve with age. In addition to visible improvements in skin quality, a noticeable enhancement of the jawline and a natural lifting of the facial contours can be observed.

Components of the System

Mec Regenerate® is an intelligent extracellular matrix regeneration system. Its components (four pillars) activate at specific phases following administration, initiating a long-term rebuilding process aligned with the skin’s natural biological rhythm. The goal is to restore type I collagen, type III collagen, and elastin, resulting in visible improvements in skin firmness, density, elasticity, and resilience.

Type 1 Collagen 1 – a patented recombinant α1 chain of type I collagen, produced by silkworms, is 99.9% identical to human collagen. Now in its 60th generation, silkworms consistently produce collagen with uniform structure and quality. It demonstrates high structural and thermal stability, with no risk of animal-borne pathogen transmission. The α1 chain acts as a biomimetic signal for fibroblasts.

Pro-Elastin – ey amino acids (glycine, valine, alanine, proline) that form the fundamental building blocks of elastin – the protein responsible for skin elasticity and resilience. This complex precisely delivers the substrates (“building blocks”) required for targeted elastin remodeling, while also serving as “fuel” for fibroblasts, supporting collagen production. As a result, it contributes to smoother skin, improved elasticity and resilience, and increased resistance to sagging and gravitational forces.

Polycaprolactone (PCL) – a biodegradable, pharmaceutical-grade polymer in an advanced aqueous formulation, designed to avoid the adverse effects associated with solid PCL microspheres (such as granulomas or nodules). It acts as a modulator and stabilizer of regenerative signaling. As PCL gradually biodegrades, it stimulates fibroblasts to produce new endogenous collagen, leading over time to improved skin firmness and elasticity. Its slow resorption leaves behind a natural collagen network, prolonging the achieved results.

Carboxymethylcellulose (CMC) – a carrier gel forming a biocompatible hydrogel matrix. It enables even distribution of PCL and other components while stabilizing the product within the tissues. It provides an immediate, temporary lifting effect and supports hydration through its water-binding capacity, resulting in a short-term improvement in skin tension and appearance. CMC is resorbed within a few weeks, giving way to the long-term regenerative action of PCL.

What makes it different from other stimulators?

A New Approach to Biostimulation. Instead of inducing stimulation through inflammation, it works via biomimetic signaling. It opens a new chapter in advanced, safe, natural, and predictable skin biostimulation.

No Irritation. No Inflammatory Response. No Foreign Body Reaction. Its action is based on signaling modulation within the ExtraCellular Matrix environment.

A Four-Component Regenerative System. It is a system composed of four components acting in a cascading sequence. Unlike conventional products that rely on a single biostimulating ingredient supported by excipients, it delivers a coordinated, multi-level regenerative effect.

Innovative Ingredient Formulations. It contains unique formulations of well-known ingredients, including pharmaceutical-grade polycaprolactone (PCL) in an aqueous form. This eliminates the adverse effects associated with solid PCL microspheres.

Clear & Consistent Protocol

Mec Regenerate® is administered using a 22G x 57 mm cannula in the mid and lower face, employing a retrograde fanning technique. The cannula is included in the package.

1 day >

60 days >

6 months*

* if indicated

Gradually Developing Results

SThe ingredients in Mec Regenerate® act in a cascading sequence, in line with the skin’s physiology. As a result, the effects build gradually, with the first improvements visible almost immediately after treatment. The efficacy of Mec Regenerate® has been confirmed by clinical and histopathological studies.

0 > 7 days: Hydration & Plumping

Improved skin turgor, ﬁrmer texture, slight plumping and glow.

1 > 4 weeks: Collagen Remodeling

Improved skin elasticity, smoother texture, initial ﬁne line softening.

1 > 3 months: Biostimulation Onset

Volume restoration, reduction in deeper wrinkles, thighter jawline or cheek areas.

3 > 24 months: Long-Term Regeneration

Sustained lifting effects and restoration of dermal density, with improvements in overall skin quality. The biostimulatory, non-volumizing nature of PCL minimizes the risk of treatment-related pufﬁness.

Results after two treatments with MEC Regenerate®. The images are taken in frontal and 45° view. Natural light and Grayscale analysis show a visible lifting of the nasolabial fold and a harmonious reshaping of the skin surface. (fot. 303Pharma)

Results after two treatments with MEC Regenerate®. The images (frontal and 45°) show a signiﬁcant improvement in facial contour, skin elasticity and ﬁrmness, conﬁrmed by the pinch test performed before and after 2 treatments. (Fot. 303 Pharma).

Clinical Evaluation

Only a limited number of aesthetic medicine products are tested on large patient groups at the time of market introduction. 303 Pharma conducts clinical and histopathological studies in Italy with patient participation. In Poland, as many as 11 centers are involved in the observation and documentation of outcomes as part of MDR evaluation. In the United Kingdom, we collaborate with one clinical center. Observations have been ongoing since January 2026. In total, 103 patients will undergo a series of two recommended treatments spaced 60 days apart (with a third treatment after 6 months, if indicated). Outcomes are documented and evaluated by both physicians and patients. The results following the first treatment will be available soon.

MEC Regenerate® is currently in the final stage of MDR certification, in accordance with the requirements of EU Regulation 2017/745 on medical devices.

The product will soon be available in Poland and other countries. It will be available for purchase (including attractive package options) through our representatives, as well as directly via our online store (for international customers only, with prices in EUR) and via the app (for Polish physicians). With the product’s market launch, we will also introduce dedicated training programs for physicians.

App Store

Google Play